Biosynthetic Dipolar Cycloadditions

We are exploring the viability of dipolar cycloadditions in the biosynthesis of various complex natural products. Representative studies include:

Wang, S. C.; Tantillo, D. J. J. Org. Chem. 2008, 73, 1516-1523: "Theoretical Studies on Synthetic and Biosynthetic Oxidopyrylium–Alkene Cycloadditions. Pericyclic Pathways to Intricarene"

Painter, P. P.; Pemberton, R. P; Wong, B. M.; Ho, K. C; Tantillo, D. J. J. Org. Chem. 2014, 79, 432-435: "The Viability of Nitrone-Alkene (3+2) Cycloadditions in Alkaloid Biosynthesis"


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