Biosynthetic Dipolar Cycloadditions
We are exploring the viability of dipolar cycloadditions in the biosynthesis of various complex natural products. Representative studies include:
Wang, S. C.; Tantillo, D. J. J. Org. Chem. 2008, 73, 1516-1523: "Theoretical Studies on Synthetic and Biosynthetic Oxidopyrylium–Alkene Cycloadditions. Pericyclic Pathways to Intricarene"
Painter, P. P.; Pemberton, R. P; Wong, B. M.; Ho, K. C; Tantillo, D. J. J. Org. Chem. 2014, 79, 432-435: "The Viability of Nitrone-Alkene (3+2) Cycloadditions in Alkaloid Biosynthesis"
Harmange Magnani, C. S.; Hernández-Meléndez, J. R.; Tantillo, D. J.; Maimone, T. J. JACS Au 2023, 3, 2883-2893: "Total Synthesis of Altemicidin: A Surprise Ending for a Monoterpene Alkaloid"
