I'm sure you've heard of enzymes but have you heard of these?
Abzymes
Luo, G. M. Prog. Biochem. Biophys. 2000, 27, 354-359: "Recent Advances in Abzyme Studies"
AI.zymes
Merlicek, L. P.; Neumann, J.; Lear, A.; Degiorgi, V.; de Waal, M. M.; Cotet, T.-S.; Mulholland, A. J.; Bunzel, H. A. Angew. Chem. Int. Ed. 2025, 64, e202507031: "AI.zymes: A Modular Platform for Evolutionary Enzyme Design"
Antizymes
Matsufuji, S.; Matsufuji, T.; Miyazaki, Y.; Murakami, Y.; Atkins, J. F.; Gesteland, R. F.; Hayashi, S. Cell 1995, 80, 51-60: "Autoregulatory Frameshifting in Decoding Mammalian Ornithine Decarboxylase Antizyme"
Aptananozymes
Ouyang, Y.; Biniuri, Y.; Fadeev, M.; Zhang, P.; Carmieli, R.; Vázquez-González, M.; Willner, I. J. Am. Chem. Soc. 2021: "Aptamer-Modified Cu2+-Functionalized C-Dots: Versatile Means to Improve Nanozyme Activities-'Aptananozymes'"
CAZymes
Armand, M.; Nin-Hill, A; Arda, A.; Berrino, E.; Desire, J.; Martin-Mingot, A.; Michelet, B.; Jimenez-Barbero, J.; Bleriot, Y.; Rovira, C.; Thibaudeau, S. J. Am. Chem. Soc. 2024, 146, 32618-32626 : "Glycosylium Ions in Superacid Mimic the Transition State of Enzyme Reactions"
Compuzymes
Tantillo, D. J.; Houk, K. N.: "Theozymes and Catalyst Design" In Stimulating Concepts in Chemistry, Wiley-VCH: Weinheim, Germany, 2000; pp 79-88.
Coronazymes
Zuo, L.; Ren, K.; Guo, X.; Pokhrel, P.; Pokhrel, B.; Hossain, M. A.; Chen, Z.-X.; Mao, H.; Shen, H. J. Am. Chem. Soc. 2023, 145, 5750-5758: "Amalgamation of DNAzymes and Nanozymes in a Coronazyme"
Chemzymes
Corey, E. J. Pure Appl. Chem. 1990, 62, 1209-1216: "New Enantioselective Routes to Biologically Interesting Compounds"
Dendrizymes
Brunner, H.; Altmann, S. Chem. Ber. 1994, 127, 2285-2296: "Enantioselective Catalysis 90. Optically Active Nitrogen Ligands with Dendrimeric Structure"
DNAzymes
Lerner, L.; Roupioz, Y.; Ting, R.; Perrin, D. M. J. Am. Chem. Soc. 2002, 124, 9960-9961: "Toward an RNaseA Mimic: A DNAzyme with Imidazoles and Cationic Amines"
Flexizymes
Ramaswamy, K.; Saito, H.; Murakami, H.; Shiba, K.; Suga, H. J. Am. Chem. Soc. 2004, 126, 11454-11455: "Designer Ribozymes: Programming the tRNA Specificity into Flexizyme"
FNAzymes
Yang, M.; Xie, Y.; Zhu, L.; Li, X.; Xu, W. ACS Catal. 2024, 14, 16392-16422: "Functional Nucleic Acid Enzymes: Nucleic Acid-Based Catalytic Factories"
Gelozymes
Fadnavis, N. W.; Radhika, K. R.; Madhuri, K. V. Tetr. Asymm. 2004, 15, 549-553: "'Gelozymes' in Organic Synthesis. (Part 3): Lipase Mediated Synthesis of Enantiomerically Pure (R)- and (S)-Enantiomers of 2-Acetoxy-4-phenyl-(E)-but-3-enenitrile"
Granzymes
Donado, C. A.; Theisen, E.; Zhang, F.; Nathan, A.; Fairfield, M. L.; Rupani, K. V.; Jones, D.; Johannes, K. P.; Accelerating Medicines Partnership RA/SLE Network; Raychudhuri, S.; Dwyer, D. F.; Jonsson, A. H.; Brenner, M. B. Nature 2025,641, 211-221: "Granzyme K Activates the Entire Complement Cascade"
Leadzymes
Wedekind, J. E.; McKay, D. B. Biochemistry 2003, 42, 9554-9563: "Crystal Structure of the Leadzyme at 1.8 Resolution: Metal Ion Binding and the Implications for Catalytic Mechanism and Allo Site Ion Regulation"
Nanozymes
Wei, H.; Wang, E. Chem. Soc. Rev. 2013, 42, 6060-6093,: "Nanomaterials with Enzyme-like Characteristics (Nanozymes): Next-Generation Artificial Enzymes"
Photozymes
Sack, D.; Wagenknecht, H.-A. Eur. J. Org. Chem. 2021, 6400-6407: "The Concept of Photozymes: Short Peptides with Photoredox Catalytic Activity for Nucleophilic Additions to alpha-Phenyl Styrenes"
Protozymes
Bolon, D. N.; Mayo, S. L. Proc. Natl. Acad. Sci. USA 2001, 98, 14274-14279: "Enzyme-like Proteins by Computational Design"
Ribozymes
Doherty, E. A.; Doudna, J. A. Ann. Rev. Biophys. Biomolec. Struc. 2001, 30, 457-475: "Ribozyme Structures and Mechanisms"
Singzymes
Long, Z.; Wang, K.; Luo, K.; He, Q. JACS Au 2025, 5, 3058-3069: "Singzyme: A Single–Molecule Enzyme–Like Photocatalyst Powered by the Super Cage Effect"
Spiroligozymes
Kheirabadi, M.; Celebi-Olcum, N.; Parker, M. F. L.; Zhao, Q.; Kiss, G.; Houk, K. N.; Schafmeister, C. E. J. Am. Chem. Soc. 2012,134, 18345-18553: "Spiroligozymes for Transesterifcations: Design and Relationship of Structure to Activity"
Suprazymes
Hyziuk, P.; Flaibani, M.; Posocco, P.; Sashuk, V. Chem. Sci. 2024, 15, 16480-16484: "Creating a Suprazyme: Integrating a Molecular Enzyme Mimic with a Nanozyme for Enhanced Catalysis"
Synzymes
Hollfelder, F.; Kirby, A. J.; Tawfik, D. S. J. Org. Chem. 2001, 66, 5866-6874: "On the Magnitude and Specificity of Medium Effects in Enzyme-like Catalysts for Proton Transfer"
Tantillo, D. J.; Chen, J. G.; Houk, K. N. Curr. Op. Chem. Biol. 1998, 2, 743-750: "Theozymes and Compuzymes: Theoretical Models for Biological Catalysis"
Thermozymes
Bruins, M. E.; Janssen, A. E. M.; Boom, R. M. Appl. Biochem. Biotech. 2001, 90, 155-186: "Thermozymes and Their Applications - A Review of Recent Literature and Patents"
XNAzymes
Taylor, A. I.; Wan, C. J. K.; Donde, M. J.; Peak-Chew, S.-Y.; Holliger, P. Nature Chem. 2022, 14, 1295-1305: "A Modular XNAzyme Cleaves Long, Structured RNAs Under Physiological Conditions and Enables Allele-specific Gene Silencing"
Zeozymes
Hutchings, G. J. Chem. Commun. 1999, 301-306: "New Approaches to Rate Enhancement in Heterogeneous Catalysis"
