Historical Chemistry

From time to time we use modern quantum chemical computations to probe structures and reactions of historical interest, sometimes in collaboration with the fantastic historian of chemistry, Jeff Seeman.

Tantillo, D. J. Org. Lett. 2016, 18, 4482-4484: "Does Nature Know Best? Pericyclic Reactions in the Daphniphyllum Alkaloid-Forming Cation Cascade"

Seeman, J. I.; Tantillo, D. J. Angew. Chem. Int. Ed. 2020, 59, 10702-10721: "From Decades to Minutes. Steps Toward the Structure of Strychnine 1910-1948 and the Application of Today’s Technology"

Tantillo, D. J.; Seeman, J. I. Chem. Eur. J. 2021, 27, 7000-7016: "On the Structural Assignments Underlying R. B. Woodward’s Most Personal Data That Led to the Woodward–Hoffmann Rules: Subramania Ranganathan’s Key Role and Related Research by E. J. Corey and A. G. Hortmann"

Tantillo, D. J.; Seeman, J. I. Chem. Sci. 2022, 13, 11461-11486: "Understanding Chemistry: From 'Heuristic (Soft) Explanations and Reasoning by Analogy' to 'Quantum Chemistry'"


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