This course will provide an introduction to the chemical principles behind the design and production of pharmaceutical agents.
This class is not about memorization. It is about developing analytical thinking and problem solving skills.
Outline (subject to change):
Intro to drug discovery: natural products, lead compounds (1, 2.1)
lead modification (2.2A-E)
lead modification (2.2F-G)
enzyme structure and function (4.1-4.3)
enzyme inhibition 1 (5.1-5.4B)
enzyme inhibition 2 (5.4C-5.5)
DNA/RNA issues (6)
metabolism, toxicity (7)
prodrugs, drug delivery, ion channels (8)
visit from a Sundeep Dugar, a practicing pharmaceutical chemist from industry
the big picture